How it works

Lodestone Biomedical’s Immunotherapy Response Indication System (IRIS) interrogates the binding states of functionalized magnetic nanoparticles (fMNPs) localized in needle-implantable biosensor probes for real-time monitoring of signals of efficacy and treatment response within the tumor-immune microenvironment (TIME).

Key Features

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Multiple probe readouts
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Multiplex analyte detection
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Minimally invasive
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Readings in minutes
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In vivo viability for 2 weeks
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Picogram/ml detection range
Products
IRIS Biosensor Probes

IRIS BIOSENSOR PROBES

Lodestone’s IRIS biosensor probes enable longitudinal in vivo monitoring of cytokine levels and other molecules. The probes contain magnetic nanoparticles that are functionalized to bind to the targeted molecule. A size-selective membrane retains the nanoparticles but allows the targeted molecules to enter the probe and bind to the nanoparticles. Lodestone's measurement systems track the target molecule concentration with magnetic signals from the nanoparticles.

IRIS NANOPARTICLE CHARACTERIZATION SYSTEM (NCS)

Lodestone’s NCS is a liquid cooled spectrometer which can characterize smallest amounts of magnetic nanoparticles in complex field patterns. The multi-coil spectrometer is capable of analyzing the magnetic particle response of Lodestone's probes in an in vitro setting in different media.

IRIS Nanoparticle Characterization System
IRIS Small Animal Nanoparticle Spectrometer

IRIS SMALL ANIMAL NANOPARTICLE SPECTROMETER (SNS)

Lodestone’s first in vivo measurement system allows scientists to accelerate preclinical drug development. With the SNS multiple probes can be measured per mouse in as little as 30 seconds per measurement. Collect longitudinal measurement data in your region of interest for up to seven days after implantation.

Case Study
Case Study

Norris cotton Cancer Center

Dartmouth-Hitchcock Medical Center is the preclinical research site for a Phase I SBIR contract with the National Cancer Institute. The project aims to demonstrate preclinical monitoring of treatment response in a glioblastoma model with combination immunotherapy.

"The biggest advantage of the Lodestone technology is that it can give us a continuous readout in real time to define treatment efficacy.”

-Professor Arti Gaur,
Dartmouth-Hitchcock Medical Center

Find the answers to our frequently asked questions here

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What can Lodestone do for you?

Leverage our development services for customized in vivo assays and accelerate your pre-clinical research.

Request a Free Consultation